Posted by Sarah Showard | Apr 06, 2016 | 0 Comments

The FDA issued a warning on Tuesday April 5, 2016 that diabetes drugs containing Saxagliptin and Alogliptin may increase the risk of heart failure.  The drugs containing these ingredients are:

  • Onglyza
  • Kombiglyze XR
  • Nesina
  • Kazano
  • Oseni 

The warning comes as a result of two large trials done involving patients with heart disease.  Both trials found that more patients taking these drugs were hospitalized for heart failure than patients receiving a placebo.  The risk is increased in those patients with heart or kidney disease.

Patients on these drugs should contact their doctor if they develop signs or symptoms of heart failure including:

  • Unusual shortness of breath during daily activities.
  • Difficulty breathing when lying down.
  • Tiredness, weakness or fatigue.
  • Weight gain with swelling of the ankles, feet, legs or stomach.

The FDA is adding new warnings to the drug labels regarding these safety concerns and asking physicians to consider discontinuing medications containing Saxagliptin and Alogliptin in patients who develop heart failure. 

Patients should discuss any symptoms or side effects with their doctor before changing medications. 

Showard Law Firm is your local law firm for drug and medical device claims. If you or a loved one have been injured by a defective drug or medical device contact us at 520-622-3344 for a free consultation today.

About the Author

Sarah Showard

Sarah Showard graduated from the University of Maryland in 1985, Magna Cum Laude with a Bachelor of Arts in English-Linguistics and a Certification in Women's Studies. She then graduated from New York University School of Law in 1988. Sarah began practice initially as an insurance defense attorney, and has been representing plaintiffs since 1990. Sarah has a son, Benjamin, who recently graduated from The Gregory School and will attend ASU in the fall, with future plans to attend law school and eventually join Showard Law Firm. In her spare time Sarah enjoys horseback riding and spending time in Sonoita with her husband Peter.


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